簡介:piclozotan (anhydrous), a 5-ht1a receptor agonist, demonstrated significant neuroprotective activity in a transient middle cerebral artery occlusion (t-mcao) model, ameliorating motor complications in patients with advanced parkinson´s disease.
簡介:physapubenolide is natural cytotoxic withanolide antitumor agent. physapubenolide induces apoptosis by decreasing mitochondrial membrane potential and elevating the bax/bcl-2 protein expression ratio.
簡介:phps1 is an inhibitor of shp2. phps1 efficiently inhibits activation of erk1/2 by the leukemia-associated shp2 mutant, shp2-e76k, and blocks the anchorage-independent growth of a variety of human tumor cell lines.
簡介:plumbagin (plumbaein) is a yellow dye, formally derived from naphthoquinone. it is named after the plant genus plumbago, from which it was originally isolated. it is also commonly found in the carnivorous plant genera drosera and nepenthes. it is also a component of the black walnut drupe.
簡介:photoregulin1 is a modulator of nr2e3. photoregulin1 slows the progression of photoreceptor degeneration in two common mouse models of autosomal dominant rp, the rhop23h and the pde6brd1 mutations.
簡介:phe-pro-arg-paba-resorufin is a chromogenic and fluorogenic peptide substrate for the highly sensitive detection of proteases in biological matrices. the substrate is also applicable to the sensitive detection of the thrombin inhibitor dabigatran in human plasma and whole blood samples.
簡介:phenoprolamine hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. phenoprolamine hydrochloride inhibits cyp2d and cyp3a activities and down-regulates their mrna transcription and protein expression. phenoprolamine hydrochloride can efficiently penetrate through blood brain barrier and inhibit the contraction of vascular smooth muscle in the brain.
簡介:phloracetophenone (1-(2,4,6-trihydroxyphenyl)ethanone) has antiobesity and hypolipidemic effects, may be partly mediated by delaying the intestinal absorption of dietary fat by inhibiting pancreatic lipase activity.
簡介:phenanthriplatin, also known as cis-[pt(nh3)2-(phenanthridine)cl]no3, is a new drug candidate. it belongs to a family of platinum(ii)-based agents which includes cisplatin, oxaliplatin and carboplatin. phenanthriplatin acts as a covalent poison of topoisomerase ii cleavage complexes. phenanthriplatin exhibits significantly greater activity than cisplatin and oxaliplatin. the cellular uptake of phenanthriplatin is substantially greater than that of cisplatin and pyriplatin because of the hydropho
簡介:pfn1-in-c2, an inhibitor of profilin1 (pfn1), has been shown to reduce the overall level of cellular filamentous (f)-actin, slow ec migration and proliferation, and inhibit the angiogenic ability of ec both in vitro and ex vivo.
簡介:pfn1-in-c1, an inhibitor of profilin1 (pfn1), has been shown to reduce the overall level of cellular filamentous (f)-actin, slow ec migration and proliferation, and inhibit the angiogenic ability of ec both in vitro and ex vivo.
簡介:pf-9404c is the s-s diesteroisomer of a beta adrenergic receptors blocker with vasodilatory properties. pf9404c increased the formation of cyclic gmp from 3 pmol mg?1 protein in basal conditions, to 53 pmol mg?1 protein in 10 μm in rat aorta smooth muscle cells.
簡介:pf-5274857 is a potent, orally active and selective inhibitor of hedgehog (hh) signaling pathway (ic50 = 5.8 nm, ki = 4.6 nm) . pf-5274857 effectively penetrates the blood-brain barrier and inhibits smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates.