簡(jiǎn)介:methylglutaric acid is a leucine metabolite. a large amount of methylglutaric acid is identified in urine of patients with deficiency of 3-methylglutaconyl coenzyme a hydratase (pmid 6181239 ). methylglutaric acid is also found to be associated with 3-hydroxy-3-methylglutaryl-coa lyase deficiency, another inborn error of metabolism.
簡(jiǎn)介:5-methoxy-5-oxopentanoic acid (mono-methyl glutarate) is a metabolite of dibasic esters(dbes) by nasal respiratory and olfactory mucosae in vitro demonstrated that hydrolysis of dbes yields mainly the monomethyl esters (monomethyl adipate, monomethyl. glutarate, and monomethyl succinate).
簡(jiǎn)介:trans-cyclohexane-1,2-diol (trans-1,2-cyclohexanediol) has a synergistic retardation effect on percutaneous absorption and penetration of metronidazole (mtz).
簡(jiǎn)介:l-pipecolic acid (l-homoproline) is a breakdown product of lysine, accumulates in body fluids of infants with generalized genetic peroxisomal disorders, such as zellweger syndrome, neonatal adrenoleukodystrophy.
簡(jiǎn)介:the 4-carboxyaldehyde form of vitamin b6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid.
簡(jiǎn)介:ksd 2405 (3-hydroxybenzyl alcohol) is a hydroxybenzyl alcohol that is phenol substituted at position c-3 by a hydroxymethyl group. it is a pink or beige to brown crystalline powder, soluble in water.
簡(jiǎn)介:urocanic acid (4-imidazoleacrylic acid), synthesized in the epidermis, functions as a primary absorber of ultraviolet (uv) radiation in mammalian skin.
簡(jiǎn)介:l-homoserine ((s)-(-)-2-amino-4-hydroxybutyric acid) is a more reactive variant of the amino acid serine. in this variant, the hydroxyl side chain contains an additional ch2 group which brings the hydroxyl group closer to its own carboxyl group, allowing it to chemically react to form a five-membered ring. this occurs at the point that amino acids normally join to their neighbours in a peptide bond. l-homoserine is therefore unsuitable for forming proteins and has been eliminated from the repert
簡(jiǎn)介:2,3-diaminopropanoic acid hydrochloride (3-amino-dl-alanine monohydrochloride) is an amino acid amide used as a substrate for studying the action of aminopeptidase enzyme.
簡(jiǎn)介:imidazoleacetic acid hydrochloride (i4aa) is an imidazole derivative with potential antituberculosis properties. it also used in the preparation of acyl guanidine inhibitors of β-secretase.
簡(jiǎn)介:1-aminocyclopropane-1-carboxylic acid (acc) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. it is a small molecule agonist at the glycine modulatory site of the nmda receptor (ec50 = 0.7-0.9 μm) in the presence of low levels (1 μm) of glutamate and as a competitive antagonist at the glutamate-binding site on nmda receptors (ec50 = 81.6 nm) with high levels (10 μm) of glutamate.2 this compou
簡(jiǎn)介:(2r,3r)-butane-2,3-diol (levo-2,3-butanediol) is found in cocoa and cocoa products. (2r,3r)-2,3-butanediol is isolated from cocoa butter and roots of ruta graveolens (rue).2,3-butanediol is one of the constitutional isomers of butanediol. the 2r,3r stereoisomer of 2,3-butanediol is produced by a variety of microorganisms, in a process known as butanediol fermentation. it is found in cocoa butter and in the roots of ruta graveolens.
簡(jiǎn)介:squalene (addavax) is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though there are botanical sources as well, including rice bran, wheat germ, and olives. all higher organisms produce squalene, including humans. squalene is an intermediate product in the synthesis of cholesterol and shows several pharmacological properties such as hypolipidemic, hepatoprotective, cardioprotective, antioxidant, and antitoxicant activity.
簡(jiǎn)介:1,4-dioxane-2,5-diol (glycolaldehyde dimer) is derivative of glycolaldehyde, which is the precursor molecule of various significant compounds including amino acid glycine and in the formose reaction.
簡(jiǎn)介:3-methyl-2-buten-1-ol (gamma-dimethylallylalcohol) is found in blackcurrant. 3-methyl-2-buten-1-ol is a constituent of ylang-ylang and hop oils. 3-methyl-2-buten-1-ol is found in orange peel oil and various fruits e.g. orange, lemon, lime, grape, pineapple, purple passion fruit, loganberry etc. prenol is a flavouring ingredient
簡(jiǎn)介:purine (7h-imidazo(4,5-d)pyrimidine) is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. two of the bases in nucleic acids, adenine and guanine, are purines. purines from food (or from tissue turnover) are metabolised by several enzymes, including xanthine oxidase, into uric acid. high levels of uric acid can predispose to gout when the acid crystalises in joints; this phenomenon only happens in humans and some animal species (e.g. dogs) that
簡(jiǎn)介:5-hydroxyindole-3-acetic acid (5-hiaa) is a breakdown product of serotonin that is excreted in the urine. serotonin and 5hiaa are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors (nci).
簡(jiǎn)介:n-formylglycine is a simple dipeptide and a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.
簡(jiǎn)介:elaidic acid (trans-oleic acid) is the 9-trans isomer of oleic acid. it is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils. in human platelets incubated with arachidonic acid, elaidic acid inhibits hht and hete formation while inducing prostaglandin and thromboxane synthesis.
簡(jiǎn)介:sodium creatine phosphate dibasic tetrahydrate (creatine phosphate disodium salt tetrahydrate) mainly exists in the skeletal muscles of vertebrates. it is a substrate for the determination of creatine kinase and can be used for the regeneration of atp during skeletal muscle contraction.
簡(jiǎn)介:sodium 2-hydroxybutanoate (alpha-hydroxybutyrate) is formed as a by-product of the formation of alpha-ketobutyrate via a reaction catalyzed by lactate dehydrogenase (ldh) or alpha-hydroxybutyrate dehydrogenase (alphahbdh).
簡(jiǎn)介:suberic acid (1,8-octanedioic acid) is present in the urine of patients with fatty acid oxidation disorders. a metabolic breakdown product derived from oleic acid. elevated levels of this unstaruated dicarboxylic acid are found in individuals with medium-chain acyl-coa dehydrogenase deficiency (mcad). suberic acid is also associated with carnitine-acylcarnitine translocase deficiency, malonyl-coa decarboxylase deficiency.
簡(jiǎn)介:l-carnosine (karnozin) is is an antioxidant naturally found in skeletal muscle, brain tissue. it has the potential to suppress many of the biochemical changes that accompany aging.
簡(jiǎn)介:4-acetamidobutanoic acid (4-acetamidobutyric acid) can be found in blood, feces, and urine, as well as in human prostate tissue. 4-acetamidobutanoic acid exists in all eukaryotes, ranging from yeast to humans. 4-acetamidobutanoic acid is a gaba derivative, a product of the urea cycle and the metabolism of amino groups, and the product of nad-linked aldehyde dehydrogenase (ec 1.2.1.3) (kegg).
簡(jiǎn)介:taurolithocholic acid sodium salt (sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic m1, but not to m2 or m3 receptors.