簡介:luseogliflozin (ts 071) hydrate, a second-generation sodium-glucose co-transporter 2 (sglt2) inhibitor, exhibits selective potency and oral activity, with an ic50 of 2.26 nm. this compound is utilized in research for the treatment of type 2 diabetes mellitus (t2dm).
簡介:bgn3 is a good substrate for the snap- tag and h 5 enzymes. the activities of snap- tag and h 5 enzymes on bgn3 are reasonable (ic 50 = 15.6 and 23.5 μm, respectively).
簡介:neopuerarin b, an isoflavone derived from the aqueous extract of dried pueraria lobata (willd.) roots, exhibits notable hepatoprotective properties.
簡介:neopuerarin a, an isoflavone derived from the aqueous extraction of dried roots of pueraria lobata (willd.), displays notable hepatoprotective activity.
簡介:7-tfa-ap-7-deaza-dda (compound 19c, us20060281100a1), a nucleotide derivative, is suitable for synthesizing thiotriphosphate nucleotide dye terminators used in dna sequencing reactions.
簡介:7-tfa-ap-7-deaza-ddg (compound 19d, us20060281100a1), is a nucleotide derivative employed in the production of thiotriphosphate nucleotide dye terminators. these terminators are utilized in dna sequencing reactions.
簡介:5-propargylamino-ddutp is a nucleoside molecule employed for the synthesis of cyanine dye-nucleotide conjugates, commonly used in nucleic acid labeling and sequence analysis.
簡介:5-propargylamino-ddctp is a nucleoside molecule utilized in the synthesis of cyanine dye-nucleotide conjugate, which finds application in nucleic acid labeling and sequence analysis.
簡介:during the sulfur-fumigation process of paeoniae radix alba, paeoniflorin, which serves as a principal constituent, can be converted into paeoniflorin sulfite.
簡介:aminohexylgeldanamycin (ahgdm) hydrochloride is a geldanamycin derivative and a powerful inhibitor of hsp90. it exhibits significant antiangiogenic and antitumor properties.
簡介:patamostat mesylate (e-3123) is a highly potent protease inhibitor, displaying strong inhibitory activity against trypsin, plasmin, and thrombin, with ic 50 values of 39 nm, 950 nm, and 1.9 μm, respectively. this compound, patamostat mesylate, shows promising potential in suppressing the pathogenesis and development of acute pancreatitis.
簡介:benzyl-peg8-ots is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
簡介:yb-0158 (wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (cscs) by disrupting the interaction between sam68 and src proteins. this compound acts as a reverse-turn agent, inducing apoptosis in crc cells and displaying strong anti-cancer activities.
簡介:ascr#7, an ascaroside-based hormonal compound, plays a significant role in nematode physiology. it is specifically expressed throughout the various stages of nematode development. notably, ascarosides exhibit the capability to initiate the formation of dauer larvae, which are characterized by their long lifespan and exceptional stress resistance.
簡介:2,3-dehydro-3,4-dihydro ivermectin, an ivermectin analog and anthelmintic, demonstrates efficacy against l. amazonensis promastigotes and amastigotes, with ic50 values of 13.8 and 3.6 ?m, respectively, while maintaining a low cytotoxicity profile in macrophages (ic50 = 65.5 ?m).
簡介:awl-ii-38.3 is a highly effective inhibitor of epha3, a receptor for ephrin-a. it demonstrates potent kinase inhibitory activity against epha3 and does not show significant cellular activity against src-family kinases or b-raf [1] [2].
簡介:abt-072, also known as potassium trihydrate, is a highly effective non-nucleoside inhibitor of the hcv ns5b polymerase, administered orally. this compound exhibits potent activity against hcv gt1a (with an ec50 of 1 nm) and hcv gt1b (with an ec50 of 0.3 nm).
簡介:vicenin 2 is an angiotensin-converting enzyme (ace) inhibitor (ic50=43.83 μm) from the aerial parts of desmodium styracifolium. vicenin 2 is an inhibitor of α-glucosidase, ptp1b, and rlar. vicenin 2 has hepatoprotective, anti-cancer, antioxidant and anti-inflammatory activities, and dtl co-administration is more effective than either of the single agents in androgen-independent prostate cancer. vicenin 2 might be a useful lead for the development of multiple target-oriented therapeutic modalitie
簡介:propanol-peg3-ch2oh is a peg-based linker for protacs which joins two essential ligands, crucial for forming protac molecules. this linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
簡介:renzapride (brl 24924) is a mixed 5-hydroxytryptamine type 4 (5-ht4) agonist and 5-ht3 receptor antagonist.renzapride can be used in the study of constipation-predominant irritable bowel syndrome (c-ibs).